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Thomas J. Long School of Pharmacy and Health Sciences

William K. Chan, Pharm.D., Ph.D.

Professor, Medicinal Chemistry

At Pacific Since:
1996

Education:
Ph.D., University of California, SanFrancisco
Pharm.D., University of California, San Francisco

Post-Doctoral / Graduate Training:
University of California, Davis, 1 year
Northwestern University Medical School, 4 years

Research Interests:

  • AH-receptor and pregnane Xreceptor research
  • Cytochrome P450 mediated drug interactions
  • Recombinant Protein Expression


Research Summary:
Our laboratory primarily utilizes biochemical and molecular biological approaches to understand basic cell signaling mechanisms that relate to induction of drug metabolizing and glycolytic enzymes, cell cycle control, angiogenesis, and steroid hormone function. Our end goal is to develop therapeutic agents that are effective for treatment of diseases such as cancer. We are interested in (1) studying the protein-protein and protein-DNA interactions in the aryl hydrocarbon receptor signaling pathway; (2) studying the Arnt-dependent signaling cross-talks (involving the aryl hydrocarbon receptor, the hypoxia inducible factor-1 alpha and the estrogen receptor signaling mechanisms) and (3) designing and generating protein therapeutics for cancer treatment, in particularly the solid tumors such as the estrogen receptor-positive breast cancer.

Dr. William Chan Lab Blog 
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