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Thomas J. Long School of Pharmacy and Health Sciences

James A. Uchizono, Pharm.D., Ph.D.

Director, Pre-Health Programs Associate Professor of Pharmaceutics

At Pacific Since
2000

Education
Ph.D., University of California at San Francisco, 2001
Pharm.D., University of California at San Francisco, 1990
B.S., Biology, University of California at Irvine, 1985
B.S., Chemistry, University of California at Irvine, 1985

Post-Doctoral / Graduate Training
Internship, Genentech, Inc., 1992

Research Interests

General:

Mathematical modeling of time- and state-varying, linear and non-linear, pharmacological and biological cascades, mechanisms, and responses.

Specific:

  • Modeling in vivo and in vitro SSRI data (Serotonin Selective Reuptake Inhibitor)
  • Pharmacodynamic modeling of 5-HT1A autoreceptor modulation on serotonin (5-HT) release.
  • Kinetics of SSRI distribution and transport across the Blood Brain Barrier (BBB) using microdialysis (MD) and cell culture models.
  • Pharmacokinetic modeling of SSRI distribution in major organs.
  • Population pharmacokinetics (PPK/PPD)
  • Development of validation methods: Cross-validation, Posterior predictive check, etc.
  • Development of statistics to evaluate pharmacometrics.

Misc:

  • Modeling of nitroglycerin drug tolerance in LLC-PK1 cell cultures.
  • Modeling of Cytochrome P-450 enzyme induction (CYP1A1) in HepG2 cell culture.
  • Modeling of Ca(2+) kinetics in A549 and A549-Taxol24 cell cultures.
  • Statistical analysis of steady-state and time-series data.